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KMID : 1134220070270010020
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Hanyang Medical Reviews
2007 Volume.27 No. 1 p.20 ~ p.28
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Transporters and Nuclear Hormone Receptors associated with Cholesterol Metabolism in Gallbladder Epithelial Cells
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Lee Jin
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Abstract
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Bile is concentrated in the gallbladder, and is often supersaturated in terms of cholesterol concentration. Such high levels of cholesterol in gallbladder bile has clinical implications with respect to cholesterol gallstone formation. Gallbladder
epithelial cells (GBEC) are exposed to high cholesterol concentrations on their apical surface. Therefore, GBEC are uniquely positioned to play an important role in modulating biliary cholesterol concentration. Recently, it has been documented that the key-transporter for polarized cholesterol and phospholipid efflux in GBEC is ATP-binding cassette transporter A1 (ABCA1) and liver X receptor (LXR )/retinoid X receptor (RXR) in the nucleus of GBEC which regulates
ABCA1 expression. In addition, it also has been demonstrated that ligands of peroxisome proliferator- activated receptor (PPAR ) and PPAR modulate inflammation and affect ABCA1 expression in GBEC. This evidence proves that GBEC
has a perfect system for cholesterol transport.
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KEYWORD
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Gallbladder, Cholesteriol, ABCA1, LXR
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